Waste Copper Cable Wire Granulator

Gofine Machine, establish in 2010, located in Longgang Developed Zone of Xingyang City, Henan, China, specially engaged in producing fertilizer production machinery, animal feed machinery, waste recycling machinery and trading in building machinery and food machinery and wood machinery;  we have heavy standardization industrial plants with area 60000 square meter, bring advanced large metal processing equipment, including the 10 sets CNC machining center, 3sets laser cutting machine, and other equipment reaching total 100 sets; we have get known by the ISO9001-20001 certification and CE certification; Welcome you to know us more on our machine and our technology.

We take "Quality First and Customer Supreme" as our business philosophy, adhere business idea"Honesty and Excellence" and spirit of "Practical and Innovative", act "Attitude is everything" to our business and each client.

Gofine Machine, establish in 2010, located in Longgang Developed Zone of Xingyang City, Henan, China, specially engaged in producing fertilizer production machinery, animal feed machinery, waste recycling machinery and trading in building machinery and food machinery and wood machinery;  we have heavy standardization industrial plants with area 60000 square meter, bring advanced large metal processing equipment, including the 10 sets CNC machining center, 3sets laser cutting machine, and other equipment reaching total 100 sets; we have get known by the ISO9001-20001 certification and CE certification; Welcome you to know us more on our machine and our technology.

We take "Quality First and Customer Supreme" as our business philosophy, adhere business idea"Honesty and Excellence" and spirit of "Practical and Innovative", act "Attitude is everything" to our business and each client.

Pyrimidine series intermediates

Pyrimidine, also known as 1,3-diazepine, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by replacing 2 carbons in the meta-position of benzene with 2 nitrogen atoms, and is a diazine. Like pyridine, pyrimidine retains its aromaticity.

Introduction

Name: Pyrimidine

Molecular formula: C4H4N2

Molar mass: 80.09 g/mol

Density: 1.016 g/ml

Melting point: 20 - 22 °C

Boiling point: 123 - 124 °C

CAS Number: 289-95-2

EINECS Number: 206-026-0

SMILES: C1=NC=NC=C1

Application

(1) Anticancer drugs. In the selection of anticancer substances, it is crucial that there are significant differences between tumor tissues and normal tissues, that is, they have a certain ability to recognize target cells. Porphyrin compounds have special affinity for cancer cells due to their unique structures, and they can selectively stay in cancer tissues. The research of it as a localizing agent and a drug for diagnosis and treatment of cancer has already aroused great interest of chemists, medical scientists and biologists. 5-Fluorouracil is a widely used anti-metabolite and anti-tumor drug in clinic. It has inhibitory effect on various tumors. It has good clinical effect in the treatment of colorectal cancer, gastric cancer, breast cancer and other cancers. Polyesters, polyester hydrocarbons, polyester amides, deoxyribonucleic acid, furans, 5-fluorouracil derivatives linked to nitroxide radicals all have antitumor effects.

(2) Anti-AIDS drugs. Viral diseases have become one of the most harmful diseases to human beings, especially the spread of AIDS, which has aroused widespread concern. There are many kinds of anti-AIDS drugs that have been approved by the US Food Administration (FDA), many of which are nucleoside compounds. In order to reduce the toxicity of drugs and improve their efficacy, scientists have begun to turn their attention to the study of non-nucleoside compounds, and such compounds have become the focus of antiviral drug research.

Synthetic method

Pyrimidines and various substituted pyrimidines are synthesized in a variety of ways. For example, barbituric acid (2,4,6-trihydroxypyrimidine) can be obtained by the condensation of urea and diethyl malonate under the action of sodium alkoxide. Barbituric acid and phosphorus oxychloride are heated together to obtain 2,4,6-trichloropyrimidine, which reacts with sodium methoxide to obtain trimethoxypyrimidine. Chloropyrimidines react with ammonia or primary and secondary amines to generate the corresponding aminopyrimidines. The derivatives of pyrimidine, cytosine, uracil and thymine, are the constituent parts of nucleic acid and deoxynucleic acid, and the pyrimidine part in the vitamin B1 molecule is a 4-amino-2-methyl-5-pyrimidine methyl group. Many oral long-acting sulfa drugs are derivatives of pyrimidine and its isomers.

The 2,4-dichloropyrimidine is prepared by reduction reaction in the presence of palladium, magnesium oxide and activated carbon.

Pyrimidine Series Intermediates,2-Chloro-5-Methylpyrimidine,5-Bromo-2-chloropyrimidine,2 4-Dichloro-5-Methylpyrimidine

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